Brain Cancer: Glioblastoma EGFRvIII SVM Index

This application provides the detection of EGFRvIII mutation status of de novo glioblastoma patients by using baseline pre-operative multi-parametric MRI analysis [1].

REQUIREMENTS:

1. Co-registered Multimodal MRI: T1, T1-Gd, T2, T2-FLAIR, DTI-AX, DTI-FA, DTI-RAD, DTI-TR, DSC-PH, DSC-PSR, DSC-rCBV.
2. Segmentation labels of the tumor sub-regions: Non-enhancing tumor core (Label=1), Enhancing tumor core (Label=4), Edema (Label=2)
3. Clinical data: A csv file having patient's demographics (Note that the CSV file should be in ASCII format). Should have age (in first column) and EGFRvIII status (in second column, binarized values like 0 and 1) for training a new model, and age only for mutation detection of new patients.
4. The data for each patient should be organized in the following directory structure.
   • Subject_ID
     1. features.csv file
     2. CONVENTIONAL
        • "my_T1_file.nii.gz"
        • "my_T2_file.nii.gz"
        • "my_T1CE_file.nii.gz"
        • "my_FLAIR_file.nii.gz"
     3. DTI
        • "my_AX_file.nii.gz"
        • "my_FA_file.nii.gz"
        • "my_RAD_file.nii.gz"
        • "my_TR_file.nii.gz"
     4. PERFUSION
        • "my_rCBV_file.nii.gz"
        • "my_PSR_file.nii.gz"
        • "my_PH_file.nii.gz"
     5. SEGMENTATION
        • "original_segmentation_file.nii.gz"
        • "segmentation_file_in_atlas_space.nii.gz"
5. The data of multiple patients should be organized in the above mentioned structure and reside under the same folder, e.g.:
   • Data_of_multiple_patients
     1. Subject_ID1
     2. Subject_ID2
     3. ...
     4. Subject_IDn

USAGE:

• Train New Model:
  1. "Select Subjects". Select the input directory (e.g., Data_of_multiple_patients) that follows the folder structure described above.
  2. "Output". Select the folder where the trained model will be saved.
  3. A pop-up window appears displaying the completion of model building (time depends on the number of patients: ~2*patients minutes).
  4. This application is also available as with a stand-alone CLI for data analysts to build pipelines around, using the following example command:

     EGFRvIIIIndexPredictor.exe -t 0 -i C:/EGFRvIIIInput -o C:/EGFRvIIIModel
     

• Use Existing Model
  1. "Model Directory". Choose the directory of a saved model.
  2. "Test Subjects". Select the input directory (e.g., Data_of_multiple_patients) that follows the folder structure described above.
  3. "Output". Select the output directory where a .csv file with the mutation status for all patients will be saved, and click on 'Confirm'.
  4. A pop-up window appears displaying the completion of result calculation. The window will also show the detected mutation status of the first subject in the Data_of_multiple_patients folder (runtime depends on the number of patients: ~2*patients minutes).
  5. This application is also available as with a stand-alone CLI for data analysts to build pipelines around, using the following example command:

     EGFRvIIIIndexPredictor.exe -t 1 -i C:/EGFRvIIIInput -m C:/EGFRvIIIModel -o C:/EGFRvIIIOutput
     

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Reference:

1. H. Akbari, S. Bakas, J.M. Pisapia, M.P. Nasrallah, M. Rozycki, M. Martinez-Lage, J.J.D. Morrissette, N. Dahmane, D.M.O’Rourke, C. Davatzikos. "In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature", Neuro Oncol. 20(8):1068-1079, 2018